National Biologics Facility
Our Publications
Peer-reviewed research and innovation supported by the National Biologics Facility.
NBF-Supported Research
Publication Archive
2025
9
Safety and Immunogenicity of a Severe Acute Respiratory Syndrome Coronavirus 2 Spike Subunit Vaccine Stabilized in the Prefusion Conformation by a Second-Generation Molecular Clamp and Evaluated in Adults Aged 18–55 Years: A Randomized, Double-Blind, Active Comparator, Phase I Trial
Development of a high-affinity anti-ROR1 variable region for broad anti-cancer immunotherapy
Rapid expression of therapeutic antibodies in mammalian cells via mRNA transfection
Assessing the therapeutic potential of a panel of novel VCAM-1 antibodies using microfluidic and three-dimensional in vitro models of vascular inflammation
A nanobody-based therapeutic targeting Nipah virus limits viral escape
A novel chimeric coronavirus spike vaccine combining SARS-CoV-2 RBD and scaffold domains from HKU-1 elicits potent neutralising antibody responses
Detection of immune-mediated tumour cell death in vivo using Zirconium-89-labeled APOMAB®
A protective bispecific antibody targets both Nipah virus surface glycoproteins and limits viral escape
Enhancement of anti-sarcoma immunity by NK cells engineered with mRNA for expression of a EphA2-targeted CAR
2024
14
Amino acid degradation pathway inhibitory by-products trigger apoptosis in CHO cells
Pyroptotic cell corpses are crowned with F-actin-rich filopodia that engage CLEC9A signaling in incoming dendritic cells
mRNArchitect: Optimized design of mRNA sequences
Isolation and Characterization of Antibodies Against Vascular Cell Adhesion Molecule-1 Reveals Putative Role for Ig-like Domains 2 and 3 in Cell-to-Cell Interaction
Rational Design of Advanced Gene Delivery Carriers: Macrophage Phenotype Matters
Targeted mRNA delivery with bispecific antibodies that tether LNPs to cell-surface markers
A scalable, spin-free approach to generate enhanced induced pluripotent stem cell-derived natural killer cells for cancer immunotherapy
Limited potential of sheep as a large animal to model transfusion-related acute lung injury mediated by antibodies against human neutrophil antigen 3a
The immune checkpoint TIGIT is upregulated on T cells during bacterial infection and is a potential target for immunotherapy
Liver and pancreatic-targeted interleukin-22 as a therapeutic for metabolic dysfunction-associated steatohepatitis
EGFR Targeting of Liposomal Doxorubicin Improves Recognition and Suppression of Non-Small Cell Lung Cancer
Harnessing metabolic plasticity in CHO cells for enhanced perfusion cultivation
Targeted delivery of polo-like kinase 1 siRNA nanoparticles using an EGFR-PEG bispecific antibody inhibits proliferation of high-risk neuroblastoma
Messenger RNA-encoded antibody approach for targeting extracellular and intracellular tau
2023
5
Interim results from a phase I randomized, placebo-controlled trial of novel SARS-CoV-2 beta variant receptor-binding domain recombinant protein and mRNA vaccines as a 4th dose booster
Click-on Antibody Fragments for Customisable Targeted Nanomedicines – Site-specific Tetrazine and Azide Functionalisation through Non-canonical Amino Acid incorporation
A nanobody recognizes a unique conserved epitope and potently neutralizes SARS-CoV-2 omicron variants
Targeted Hyperbranched Nanoparticles for Delivery of Doxorubicin in Breast Cancer Brain Metastasis
Delivery of PEGylated liposomal doxorubicin by bispecific antibodies improves treatment in models of high-risk childhood leukemia
2022
8
Design and optimization of membrane chromatography for monoclonal antibody charge variant separation
Ultrasound-mediated delivery of novel tau-specific monoclonal antibody enhances brain uptake but not therapeutic efficacy
Detection of Dengue Virus 2 with Single Infected Mosquito Resolution Using Yeast Affinity Bionanofragments and Plasmonic SERS Nanoboxes
Recent advances in the production of recombinant factor IX: bioprocessing and cell engineering
Engineering death resistance in CHO cells for improved perfusion culture
A platform technology for generating subunit vaccines against diverse viral pathogens
Potential Application of Recombinant Snake Prothrombin Activator Ecarin in Blood Diagnostics
Evaluation of Phage Display Biopanning Strategies for the Selection of Anti-Cell Surface Receptor Antibodies
2021
8
Mutational and biophysical robustness in a prestabilized monobody
Amplification-Free SARS-CoV-2 Detection Using Nanoyeast-scFv and Ultrasensitive Plasmonic Nanobox-Integrated Nanomixing Microassay
Generation of Nanoyeast Single-Chain Variable Fragments as High-Avidity Biomaterials for Dengue Virus Detection
Recombinant Antibody Engineering Enables Reversible Binding for Continuous Protein Biosensing
Perfusion culture of Chinese Hamster Ovary cells for bioprocessing applications
Tau antibody isotype induces differential effects following passive immunisation of tau transgenic mice
Incorporation of Unnatural Amino Acid into Antibody Fragment for Creating a Stable Antibody Drug Conjugate
Combinatorial F-G Immunogens as Nipah and Respiratory Syncytial Virus Vaccine Candidates
2020
7
Attenuating apoptosis in Chinese hamster ovary cells for improved biopharmaceutical production
'Omics driven discoveries of gene targets for apoptosis attenuation in CHO cells
Safety, tolerability, pharmacokinetics, and immunogenicity of a human monoclonal antibody targeting the G glycoprotein of henipaviruses in healthy adults: a first-in-human, randomised, controlled, phase 1 study
Bisphosphonate Stabilized Calcium Phosphate Nanoparticles for Effective Delivery of Plasmid DNA to Macrophages
A bispecific T cell engager targeting Glypican-1 redirects T cell cytolytic activity to kill prostate cancer cells
Improved non-invasive positron emission tomographic imaging of chemotherapy-induced tumor cell death using Zirconium-89-labeled APOMAB®
Aggregates in blood filter chambers used from the plasma donations of anti-D donors: evaluation for monoclonal antibody discovery using phage display
2019
9
Dual targeting of dengue virus virions and NS1 protein with the heparan sulfate mimic PG545
Systems-level engineering and characterisation of Clostridium autoethanogenum through heterologous production of poly-3-hydroxybutyrate (PHB)
Wavelength-Dependent Fluorescent Immunosensors via Incorporation of Polarity Indicators near the Binding Interface of Antibody Fragments
Impact of Site-Specific Bioconjugation on the Interfacial Activity of a Protein Biosurfactant
Retooling phage display with electrohydrodynamic nanomixing and nanopore sequencing
Use of bacteriophage for discovery of therapeutically relevant antibodies against infectious diseases
PD-L1– and calcitriol-dependent liposomal antigen-specific regulation of systemic inflammatory autoimmune disease
Media composition modulates human embryonic stem cell morphology and may influence preferential lineage differentiation potential
Canine CD117-Specific Antibodies with Diverse Binding Properties Isolated from a Phage Display Library Using Cell-Based Biopanning
2018
4
RNA-Seq Highlights High Clonal Variation in Monoclonal Antibody Producing CHO Cells
Selection of Antibodies to Transiently Expressed Membrane Proteins Using Phage Display
Functional domain analysis of SOX18 transcription factor using a single-chain variable fragment-based approach
CD83 Antibody Inhibits Human B Cell Responses to Antigen as well as Dendritic Cell–Mediated CD4 T Cell Responses
2017
6
Overexpression of the regulatory subunit of glutamate-cysteine ligase enhances monoclonal antibody production in CHO cells
Using Peptide Aptamer Targeted Polymers as a Model Nanomedicine for Investigating Drug Distribution in Cancer Nanotheranostics
Isolation of serotype-specific antibodies against dengue virus non-structural protein 1 using phage display and application in a multiplexed serotyping assay
Targeting mesothelin receptors with drug-loaded bacterial nanocells suppresses human mesothelioma tumour growth in mouse xenograft models
Computational Identification of Antibody Epitopes on the Dengue Virus NS1 Protein
Structural basis for the hijacking of endosomal sorting nexin proteins by Chlamydia trachomatis
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